Pennogenin Tetraglycoside Induces Rat Myometrial Contraction and MLC20 Phosphorylation via PLC-IP3 and RhoA/Rho Kinase Signaling Pathways

Open Access

Peer-reviewed

Research Article

Pennogenin Tetraglycoside Induces Rat Myometrial Contraction and MLC20 Phosphorylation via PLC-IP₃ and RhoA/Rho Kinase Signaling Pathways

Limei Wang ,

Contributed equally to this work with: Limei Wang, Chao Jia, Zuyin Yu

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Chao Jia ,

Contributed equally to this work with: Limei Wang, Chao Jia, Zuyin Yu

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Zuyin Yu ,

Contributed equally to this work with: Limei Wang, Chao Jia, Zuyin Yu

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Xiaolan Liu,

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Liping Kang,

Affiliation Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China
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Yue Cong,

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Yajun Shan,

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Zhenhu Zhao,

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Baiping Ma,

Affiliation Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Yuwen Cong

* E-mail: congyw@nic.bmi.ac.cn

Affiliation Department of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China
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Phosphorylation
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Muscle contraction
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Myosins
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Glycosides
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Protein kinase signaling cascade
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Signal inhibition
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Abnormal uterine bleeding
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Fluorescence imaging
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