MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

• Andrea J. Savio,

  Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

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• Mathieu Lemire,

  Affiliation Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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• Miralem Mrkonjic,

  Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

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• Steven Gallinger,

  Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada, Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada, Department of Surgery, University of Toronto, Toronto, Ontario, Canada

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• Brent W. Zanke,

  Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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• Thomas J. Hudson,

  Affiliation Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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• Bharati Bapat

  * E-mail: BAPAT@lunenfeld.ca

  Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada, Department of Pathology, University Health Network, Toronto, Ontario, Canada

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