Notch Signaling Change in Pulmonary Vascular Remodeling in Rats with Pulmonary Hypertension and Its Implication for Therapeutic Intervention

Lina Qiao; Liang Xie; Kun Shi; Tongfu Zhou; Yimin Hua; Hanmin Liu

doi:10.1371/journal.pone.0051514

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Open Access

Peer-reviewed

Research Article

Notch Signaling Change in Pulmonary Vascular Remodeling in Rats with Pulmonary Hypertension and Its Implication for Therapeutic Intervention

Lina Qiao ,

* E-mail: iaqiao@163.com

Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Liang Xie,

Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Kun Shi,

Affiliation Department of Cardiology, Chengdu Women & Children Center Hospital, Chengdu, China
⨯
Tongfu Zhou,

Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Yimin Hua,

Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Hanmin Liu

Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯

Notch Signaling Change in Pulmonary Vascular Remodeling in Rats with Pulmonary Hypertension and Its Implication for Therapeutic Intervention

Lina Qiao,
Liang Xie,
Kun Shi,
Tongfu Zhou,
Yimin Hua,
Hanmin Liu

Published: December 12, 2012
https://doi.org/10.1371/journal.pone.0051514

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Medical hypoxia
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Pulmonary arteries
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Notch signaling
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Endothelial cells
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