Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

Jianrong L. Low; Anneta Naidoo; Gladys Yeo; Adam J. Gehring; Zi Zong Ho; Yin Hoe Yau; Susana G. Shochat; David M. Kranz; Antonio Bertoletti; Gijsbert M. Grotenbreg

doi:10.1371/journal.pone.0051397

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Open Access

Peer-reviewed

Research Article

Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

Jianrong L. Low,

Affiliations Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, (A*STAR), Singapore, Singapore, Department of Biochemistry, University of Illinois at Urbana-Champaign (UIUC), Urbana, Illinois, United States of America
⨯
Anneta Naidoo,

Affiliation Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, (A*STAR), Singapore, Singapore
⨯
Gladys Yeo,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
⨯
Adam J. Gehring,

Affiliation Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, (A*STAR), Singapore, Singapore
⨯
Zi Zong Ho,

Affiliation Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, (A*STAR), Singapore, Singapore
⨯
Yin Hoe Yau,

Affiliation Nanyang Technological University (NTU), School of Biological Sciences, Singapore, Singapore
⨯
Susana G. Shochat,

Affiliation Nanyang Technological University (NTU), School of Biological Sciences, Singapore, Singapore
⨯
David M. Kranz,

Affiliation Department of Biochemistry, University of Illinois at Urbana-Champaign (UIUC), Urbana, Illinois, United States of America
⨯
Antonio Bertoletti,

Affiliations Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, (A*STAR), Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
⨯
Gijsbert M. Grotenbreg

* E-mail: grotenbreg@nus.edu.sg

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore, Department of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
⨯

Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

Jianrong L. Low,
Anneta Naidoo,
Gladys Yeo,
Adam J. Gehring,
Zi Zong Ho,
Yin Hoe Yau,
Susana G. Shochat,
David M. Kranz,
Antonio Bertoletti,
Gijsbert M. Grotenbreg

Published: December 10, 2012
https://doi.org/10.1371/journal.pone.0051397

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