A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

Vincenzo Libri; Andrew P. Brown; Giulio Gambarota; Jonathan Haddad; Gregory S. Shields; Helen Dawes; David J. Pinato; Ethan Hoffman; Peter J. Elliot; George P. Vlasuk; Eric Jacobson; Martin R. Wilkins; Paul M. Matthews

doi:10.1371/journal.pone.0051395

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Open Access

Peer-reviewed

Research Article

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

Vincenzo Libri ,

* E-mail: v.libri@imperial.ac.uk

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom
⨯
Andrew P. Brown,

Affiliation Imanova Centre for Imaging Sciences, London, United Kingdom
⨯
Giulio Gambarota,

Affiliation GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom
⨯
Jonathan Haddad,

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America
⨯
Gregory S. Shields,

Affiliation GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom
⨯
Helen Dawes,

Affiliation Movement Sciences Group, Oxford Brookes University, Oxford, United Kingdom
⨯
David J. Pinato,

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom
⨯
Ethan Hoffman,

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America
⨯
Peter J. Elliot,

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America
⨯
George P. Vlasuk,

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America
⨯
Eric Jacobson,

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America
⨯
Martin R. Wilkins,

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom
⨯
Paul M. Matthews

Affiliations GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom, Division of Brain Sciences, Department of Medicine, Imperial College, London, United Kingdom
⨯

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

Vincenzo Libri,
Andrew P. Brown,
Giulio Gambarota,
Jonathan Haddad,
Gregory S. Shields,
Helen Dawes,
David J. Pinato,
Ethan Hoffman,
Peter J. Elliot,
George P. Vlasuk

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0051395

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