Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction

• Giordano Mancini ,

  Contributed equally to this work with: Giordano Mancini, Ilda D’Annessa

  Current address: Scuola Normale Superiore, Piazza dei Cavalieri, Pisa, Italy

  Affiliation CASPUR Inter-University Consortium for the Application of Super-Computing for Universities and Research, Rome, Italy

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• Ilda D’Annessa ,

  Contributed equally to this work with: Giordano Mancini, Ilda D’Annessa

  Affiliation Department of Biology and Centro di Bioinformatica e Biostatistica, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, Italy

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• Andrea Coletta,

  Affiliation Department of Biology and Centro di Bioinformatica e Biostatistica, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, Italy

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• Giovanni Chillemi,

  Affiliation CASPUR Inter-University Consortium for the Application of Super-Computing for Universities and Research, Rome, Italy

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• Yves Pommier,

  Affiliation Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

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• Mark Cushman,

  Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, United States of America

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• Alessandro Desideri

  * E-mail: desideri@uniroma2.it

  Affiliation Department of Biology and Centro di Bioinformatica e Biostatistica, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome, Italy

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