Signal Transduction Pathways (MAPKs, NF-κB, and C/EBP) Regulating COX-2 Expression in Nasal Fibroblasts from Asthma Patients with Aspirin Intolerance

Francesc Josep Garcia-Garcia; Joaquim Mullol; Maria Perez-Gonzalez; Laura Pujols; Isam Alobid; Jordi Roca-Ferrer; Cesar Picado

doi:10.1371/journal.pone.0051281

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Research Article

Signal Transduction Pathways (MAPKs, NF-κB, and C/EBP) Regulating COX-2 Expression in Nasal Fibroblasts from Asthma Patients with Aspirin Intolerance

Francesc Josep Garcia-Garcia,

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain
⨯
Joaquim Mullol,

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain, Unitat de Rinologia i Clínica de l’Olfacte, Servei d’Otorinolaringologia, Hospital Clínic, Barcelona, Catalonia, Spain
⨯
Maria Perez-Gonzalez,

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain
⨯
Laura Pujols,

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain
⨯
Isam Alobid,

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain
⨯
Jordi Roca-Ferrer ,

Contributed equally to this work with: Jordi Roca-Ferrer, Cesar Picado

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain
⨯
Cesar Picado

Contributed equally to this work with: Jordi Roca-Ferrer, Cesar Picado

* E-mail: idib402@clinic.ub.es

Affiliations Immunoal·lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain, Servei de Pneumologia i Al·lèrgia Respiratòria, Hospital Clinic, Universitat de Barcelona, Barcelona, Catalonia, Spain
⨯

Signal Transduction Pathways (MAPKs, NF-κB, and C/EBP) Regulating COX-2 Expression in Nasal Fibroblasts from Asthma Patients with Aspirin Intolerance

Francesc Josep Garcia-Garcia,
Joaquim Mullol,
Maria Perez-Gonzalez,
Laura Pujols,
Isam Alobid,
Jordi Roca-Ferrer,
Cesar Picado

Published: December 11, 2012
https://doi.org/10.1371/journal.pone.0051281

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Fibroblasts
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Transcription factors
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COX-2 inhibitors
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Nasal mucosa
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MAPK signaling cascades
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Protein expression
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Gene expression
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Asthma
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