Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

Naoto Kajitani; Kazue Hisaoka-Nakashima; Norimitsu Morioka; Mami Okada-Tsuchioka; Masahiro Kaneko; Miho Kasai; Chiyo Shibasaki; Yoshihiro Nakata; Minoru Takebayashi

doi:10.1371/journal.pone.0051197

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Peer-reviewed

Research Article

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

Naoto Kajitani,

Affiliations Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan, Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
⨯
Kazue Hisaoka-Nakashima,

Affiliation Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Norimitsu Morioka,

Affiliation Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Mami Okada-Tsuchioka,

Affiliation Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
⨯
Masahiro Kaneko,

Affiliation Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Miho Kasai,

Affiliation Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Chiyo Shibasaki,

Affiliations Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan, Department of Psychiatry, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
⨯
Yoshihiro Nakata,

Affiliation Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
⨯
Minoru Takebayashi

* E-mail: mtakebayashi@kure-nh.go.jp

Affiliations Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan, Department of Psychiatry, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
⨯

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

Naoto Kajitani,
Kazue Hisaoka-Nakashima,
Norimitsu Morioka,
Mami Okada-Tsuchioka,
Masahiro Kaneko,
Miho Kasai,
Chiyo Shibasaki,
Yoshihiro Nakata,
Minoru Takebayashi

Published: December 5, 2012
https://doi.org/10.1371/journal.pone.0051197

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Astrocytes
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Antidepressants
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Messenger RNA
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Gene expression
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Fibroblast growth factor
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Adrenergic signal transduction
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