Cytosolic, Autocrine Alpha-1 Proteinase Inhibitor (A1PI) Inhibits Caspase-1 and Blocks IL-1β Dependent Cytokine Release in Monocytes

Open Access

Peer-reviewed

Research Article

Yonggang Wang,

Affiliation Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Yong He,

Affiliation Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Bindu Abraham,

Affiliation Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Farshid N. Rouhani,

Affiliation Department of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Mark L. Brantly,

Affiliation Department of Medicine, University of Florida, Gainesville, Florida, United States of America
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Dorothy E. Scott,

Affiliation Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Jennifer L. Reed

* E-mail: jennifer.reed@fda.hhs.gov

Affiliation Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯

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Monocytes
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Inflammasomes
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Macrophages
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Cytokines
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Cytosol
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Immunoblotting
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Secretion
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Hypotonic
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