Unique In Vitro and In Vivo Thrombopoietic Activities of Ingenol 3,20 Dibenzoate, A Ca++-Independent Protein Kinase C Isoform Agonist

Frederick K. Racke; Maureen Baird; Rolf F. Barth; Tianyao Huo; Weilian Yang; Nilendu Gupta; Michael Weldon; Heather Rutledge

doi:10.1371/journal.pone.0051059

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Peer-reviewed

Research Article

Unique In Vitro and In Vivo Thrombopoietic Activities of Ingenol 3,20 Dibenzoate, A Ca⁺⁺-Independent Protein Kinase C Isoform Agonist

Frederick K. Racke ,

* E-mail: frederick.k.racke@questdiagnostics.com

Current address: Quest Diagnostics, San Juan, Capistrano, California, United States of America

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Maureen Baird,

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Rolf F. Barth,

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Tianyao Huo,

Current address: Department of Cardiology, College of Medicine, University of Florida, Gainsville, Florida, United States of America

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Weilian Yang,

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Nilendu Gupta,

Affiliation Department of Radiation Oncology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Michael Weldon,

Affiliation Department of Radiation Oncology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯
Heather Rutledge

Current address: Quest Diagnostics, Cincinnati, Ohio, United States of America

Affiliation Department of Pathology, The Ohio State University School of Medicine, Columbus, Ohio, United States of America
⨯

Unique In Vitro and In Vivo Thrombopoietic Activities of Ingenol 3,20 Dibenzoate, A Ca⁺⁺-Independent Protein Kinase C Isoform Agonist

Frederick K. Racke,
Maureen Baird,
Rolf F. Barth,
Tianyao Huo,
Weilian Yang,
Nilendu Gupta,
Michael Weldon,
Heather Rutledge

Published: December 21, 2012
https://doi.org/10.1371/journal.pone.0051059

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