The P2Y12 Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y12/Gi-Dependent Mechanism

Open Access

Peer-reviewed

Research Article

The P2Y₁₂ Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y₁₂/G_i-Dependent Mechanism

Binggang Xiang ,

Contributed equally to this work with: Binggang Xiang, Guoying Zhang

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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Guoying Zhang ,

Contributed equally to this work with: Binggang Xiang, Guoying Zhang

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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Hongmei Ren,

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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Manjula Sunkara,

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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Andrew J. Morris,

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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T. Kent Gartner,

Affiliation Department of Biology, University of Memphis, Memphis, Tennessee, United States of America
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Susan S. Smyth,

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Lexington VA Medical Center, Lexington, Kentucky, United States of America
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Zhenyu Li

* E-mail: zhenyuli08@uky.edu

Affiliation Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
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Platelet activation
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Platelet aggregation
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Platelets
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Phosphorylation
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Signal inhibition
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Thrombin
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Thrombosis
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Secretion
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