Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells

Changjie Lou; Fayun Zhang; Ming Yang; Juan Zhao; Wenfeng Zeng; Xiaocui Fang; Yanqiao Zhang; Chunling Zhang; Wei Liang

doi:10.1371/journal.pone.0050956

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Open Access

Peer-reviewed

Research Article

Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells

Changjie Lou,

Affiliations Department of Gastrointestinal Medical Oncology, The Affiliated Third Hospital of Harbin Medical University, Institute of Prevention and Treatment of Cancer of Heilongjiang Province, Harbin, People's Republic of China, Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Fayun Zhang,

Affiliation Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Ming Yang,

Affiliation Department of Gastrointestinal Medical Oncology, The Affiliated Third Hospital of Harbin Medical University, Institute of Prevention and Treatment of Cancer of Heilongjiang Province, Harbin, People's Republic of China
⨯
Juan Zhao,

Affiliation Department of Gastrointestinal Medical Oncology, The Affiliated Third Hospital of Harbin Medical University, Institute of Prevention and Treatment of Cancer of Heilongjiang Province, Harbin, People's Republic of China
⨯
Wenfeng Zeng,

Affiliation Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Xiaocui Fang,

Affiliation Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Yanqiao Zhang ,

* E-mail: yanqiaozhang@126.com (YQZ); zhangcl@moon.ibp.ac.cn (CLZ)

Affiliation Department of Gastrointestinal Medical Oncology, The Affiliated Third Hospital of Harbin Medical University, Institute of Prevention and Treatment of Cancer of Heilongjiang Province, Harbin, People's Republic of China
⨯
Chunling Zhang ,

* E-mail: yanqiaozhang@126.com (YQZ); zhangcl@moon.ibp.ac.cn (CLZ)

Affiliation Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Wei Liang

Affiliation Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯

Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells

Changjie Lou,
Fayun Zhang,
Ming Yang,
Juan Zhao,
Wenfeng Zeng,
Xiaocui Fang,
Yanqiao Zhang,
Chunling Zhang,
Wei Liang

Published: December 26, 2012
https://doi.org/10.1371/journal.pone.0050956

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