Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

• Christopher E. Heise ,

  * E-mail: heise.christopher@gene.com (CEH); michelle.arkin@ucsf.edu (MRA)

  Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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• Jeremy Murray,

  Affiliation Department of Structural Biology, Genentech, Inc., South San Francisco, California, United States of America

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• Katherine E. Augustyn,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• Brandon Bravo,

  Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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• Preeti Chugha,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• Frederick Cohen,

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Anthony M. Giannetti,

  Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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• Paul Gibbons,

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Rami N. Hannoush,

  Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Brian R. Hearn,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• Priyadarshini Jaishankar,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• Cuong Q. Ly,

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Kinjalkumar Shah,

  Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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• Karen Stanger,

  Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Micah Steffek,

  Affiliation Department of Structural Biology, Genentech, Inc., South San Francisco, California, United States of America

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• Yinyan Tang,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• Xianrui Zhao,

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Joseph W. Lewcock,

  Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America

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• Adam R. Renslo,

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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• John Flygare,

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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•  [ ... ],
• Michelle R. Arkin

  * E-mail: heise.christopher@gene.com (CEH); michelle.arkin@ucsf.edu (MRA)

  Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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