Analysis of 30 Putative BRCA1 Splicing Mutations in Hereditary Breast and Ovarian Cancer Families Identifies Exonic Splice Site Mutations That Escape In Silico Prediction

• Barbara Wappenschmidt ,

  Contributed equally to this work with: Barbara Wappenschmidt, Alexandra A. Becker

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Alexandra A. Becker ,

  Contributed equally to this work with: Barbara Wappenschmidt, Alexandra A. Becker

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Jan Hauke,

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany, Institute of Human Genetics, University of Cologne, Cologne, Germany

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• Ute Weber,

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Stefanie Engert,

  Affiliation Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany

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• Juliane Köhler,

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Karin Kast,

  Affiliation Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany

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• Norbert Arnold,

  Affiliation Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany

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• Kerstin Rhiem,

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Eric Hahnen,

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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• Alfons Meindl,

  Affiliation Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany

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• Rita K. Schmutzler

  * E-mail: Rita.Schmutzler@uk-koeln.de

  Affiliations Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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