Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach

• Eric S. J. Harris ,

  * E-mail: eric.sj.harris@gmail.com

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Shugeng Cao,

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Sean D. Schoville,

  Affiliation Université Joseph Fourier Grenoble, Centre National de la Recherche Scientifique TIMC-IMAG UMR 5525, Equipe Biologie Computationnelle et Mathématique, Grenoble, France

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• Chengming Dong,

  Affiliation College of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, PR China

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• Wenquan Wang,

  Affiliation School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing, PR China

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• Zaiyou Jian,

  Affiliation School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan, PR China

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• Zhongzhen Zhao,

  Affiliation School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, PR China

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• David M. Eisenberg,

  Affiliations Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Jon Clardy

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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