Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

Andrew T. N. Tebbenkamp; Keith W. Crosby; Zoe B. Siemienski; Hilda H. Brown; Todd E. Golde; David R. Borchelt

doi:10.1371/journal.pone.0050750

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Peer-reviewed

Research Article

Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

Andrew T. N. Tebbenkamp,

Affiliations Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida, United States of America
⨯
Keith W. Crosby,

Affiliations Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida, United States of America
⨯
Zoe B. Siemienski,

Affiliations Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida, United States of America
⨯
Hilda H. Brown,

Affiliations Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida, United States of America
⨯
Todd E. Golde,

Affiliation Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America
⨯
David R. Borchelt

* E-mail: borchelt@mbi.ufl.edu

Affiliations Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America, SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, Florida, United States of America
⨯

Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

Andrew T. N. Tebbenkamp,
Keith W. Crosby,
Zoe B. Siemienski,
Hilda H. Brown,
Todd E. Golde,
David R. Borchelt

Published: December 7, 2012
https://doi.org/10.1371/journal.pone.0050750

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