Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury

• Maria T. Kuipers ,

  * E-mail: Ilse.Kuipers@amc.nl

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Hamid Aslami,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Alexander P. J. Vlaar,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Nicole P. Juffermans,

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Anita M. Tuip-de Boer,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Maria A. Hegeman,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Geartsje Jongsma,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Joris J. T. H. Roelofs,

  Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Tom van der Poll,

  Affiliations Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Marcus J. Schultz,

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Catharina W. Wieland

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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