Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3

Eri Maria Sol; Sebastian A. Wagner; Brian T. Weinert; Amit Kumar; Hyun-Seok Kim; Chu-Xia Deng; Chunaram Choudhary

doi:10.1371/journal.pone.0050545

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Peer-reviewed

Research Article

Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3

Eri Maria Sol ,

Contributed equally to this work with: Eri Maria Sol, Sebastian A. Wagner

Affiliation Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Sebastian A. Wagner ,

Contributed equally to this work with: Eri Maria Sol, Sebastian A. Wagner

Affiliation Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Brian T. Weinert,

Affiliation Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Amit Kumar,

Affiliation Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Hyun-Seok Kim,

Affiliations Genetics of Development and Disease Branch, The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Life Science, Division of Life and Pharmaceutical Sciences, College of Natural Science, Ewha Womans University, Seoul, Republic of Korea
⨯
Chu-Xia Deng,

Affiliation Genetics of Development and Disease Branch, The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chunaram Choudhary

* E-mail: chuna.choudhary@cpr.ku.dk

Affiliation Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3

Eri Maria Sol,
Sebastian A. Wagner,
Brian T. Weinert,
Amit Kumar,
Hyun-Seok Kim,
Chu-Xia Deng,
Chunaram Choudhary

Published: December 7, 2012
https://doi.org/10.1371/journal.pone.0050545

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Acetylation
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Mitochondria
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Lysine
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Stable isotope labeling by amino acids in cell culture
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Immunoprecipitation
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Enzyme regulation
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Fatty acids
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Metabolic pathways
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