Prediction of Protein-Destabilizing Polymorphisms by Manual Curation with Protein Structure

• Craig Alan Gough,

  Affiliations Integrated Database Group, Japan Biological Information Research Center, Tokyo, Japan, Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Reconesis, Tokyo, Japan, Biological Informatics Consortium, Tokyo, Japan

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• Keiichi Homma,

  Affiliations Laboratory for Gene-Product Informatics, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan, Department of Bioinformatics, Maebashi Institute of Technology, Maebashi, Japan

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• Yumi Yamaguchi-Kabata,

  Affiliations Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Laboratory for Medical Informatics, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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• Makoto K. Shimada,

  Affiliations Integrated Database Group, Japan Biological Information Research Center, Tokyo, Japan, Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan, Biological Informatics Consortium, Tokyo, Japan

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• Ranajit Chakraborty,

  Affiliation Department of Forensic and Investigative Genetics, Institute of Applied Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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• Yasuyuki Fujii,

  Affiliations Integrated Database Group, Japan Biological Information Research Center, Tokyo, Japan, Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Innovation Center Okayama for Nanobio-Targeted Therapy, Graduate Schools of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan, Biological Informatics Consortium, Tokyo, Japan

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• Hisakazu Iwama,

  Affiliation Life Science Research Center, Kagawa University, Kagawa, Japan

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• Shinsei Minoshima,

  Affiliation Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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• Shigetaka Sakamoto,

  Affiliation Holonics Co., Numazu, Japan

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• Yoshiharu Sato,

  Affiliations Integrated Database Group, Japan Biological Information Research Center, Tokyo, Japan, Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Department of Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan, Biological Informatics Consortium, Tokyo, Japan

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• Yoshiyuki Suzuki,

  Affiliations Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan, Graduate School of Natural Sciences, Nagoya City University, Nagoya, Japan

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• Masahito Tada-Umezaki,

  Affiliation Laboratory for Gene-Product Informatics, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan

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• Ken Nishikawa,

  Affiliation Laboratory for Gene-Product Informatics, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan

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• Tadashi Imanishi ,

  * E-mail: t.imanishi@aist.go.jp

  Affiliation Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

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• Takashi Gojobori

  Affiliation Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan

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