A Synthetic Form of Frizzled 8-Associated Antiproliferative Factor Enhances p53 Stability through USP2a and MDM2

Jayoung Kim; Susan K. Keay; Sungyong You; Massimo Loda; Michael R. Freeman

doi:10.1371/journal.pone.0050392

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Peer-reviewed

Research Article

A Synthetic Form of Frizzled 8-Associated Antiproliferative Factor Enhances p53 Stability through USP2a and MDM2

Jayoung Kim ,

* E-mail: Jayoung.Kim@cshs.org

Affiliations Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, The Urological Diseases Research Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America, Departments of Surgery and Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Susan K. Keay,

Affiliation Division of Infectious Diseases, Department of Medicine, the University of Maryland School of Medicine and VA Maryland Health Care Center, Baltimore, Maryland, United States of America
⨯
Sungyong You,

Affiliation Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Massimo Loda,

Affiliations Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael R. Freeman

Affiliations Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, The Urological Diseases Research Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America, Departments of Surgery and Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Synthetic Form of Frizzled 8-Associated Antiproliferative Factor Enhances p53 Stability through USP2a and MDM2

Jayoung Kim,
Susan K. Keay,
Sungyong You,
Massimo Loda,
Michael R. Freeman

Published: December 6, 2012
https://doi.org/10.1371/journal.pone.0050392

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