Exposure of a Distinct PDCA-1+ (CD317) B Cell Population to Agonistic Anti-4-1BB (CD137) Inhibits T and B Cell Responses Both In Vitro and In Vivo

Open Access

Peer-reviewed

Research Article

Exposure of a Distinct PDCA-1⁺ (CD317) B Cell Population to Agonistic Anti-4-1BB (CD137) Inhibits T and B Cell Responses Both In Vitro and In Vivo

Dass S. Vinay,

Affiliation Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
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Seung J. Lee,

Affiliation Cell and Immunobiology, and R and D Center for Cancer Therapeutics, National Cancer Center, Goyang-Si, Gyeonggi-Do, Korea
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Chang H. Kim,

Affiliation Cell and Immunobiology, and R and D Center for Cancer Therapeutics, National Cancer Center, Goyang-Si, Gyeonggi-Do, Korea
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Ho Sik Oh,

Affiliation Cell and Immunobiology, and R and D Center for Cancer Therapeutics, National Cancer Center, Goyang-Si, Gyeonggi-Do, Korea
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Byoung S. Kwon

* E-mail: bkwon@tulane.edu

Affiliations Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America, Cell and Immunobiology, and R and D Center for Cancer Therapeutics, National Cancer Center, Goyang-Si, Gyeonggi-Do, Korea
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B cells
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Flow cytometry
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T cells
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Cytokines
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Cell staining
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Spleen
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Developmental signaling
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Class switching
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