Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE2 Production in Bone Marrow Derived Macrophages

Lei Xiao; Magdalena Ornatowska; Guiqing Zhao; Hongmei Cao; Rui Yu; Jing Deng; Yongchao Li; Qiong Zhao; Ruxana T. Sadikot; John W. Christman

doi:10.1371/journal.pone.0050244

Loading metrics

Open Access

Peer-reviewed

Research Article

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE₂ Production in Bone Marrow Derived Macrophages

Lei Xiao ,

* E-mail: leixiao@uic.edu

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America, The Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States of America
⨯
Magdalena Ornatowska,

Affiliation Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Guiqing Zhao,

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Hongmei Cao,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Rui Yu,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Jing Deng,

Affiliation Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Yongchao Li,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Qiong Zhao,

Affiliation Department of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Ruxana T. Sadikot,

Affiliation Department of Medicine, University of Florida and Department of Veterans Affairs, Gainesville, Florida, United States of America
⨯
John W. Christman

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, The Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States of America
⨯

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE₂ Production in Bone Marrow Derived Macrophages

Lei Xiao,
Magdalena Ornatowska,
Guiqing Zhao,
Hongmei Cao,
Rui Yu,
Jing Deng,
Yongchao Li,
Qiong Zhao,
Ruxana T. Sadikot,
John W. Christman

Published: November 30, 2012
https://doi.org/10.1371/journal.pone.0050244

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Isomerases
Is the Subject Area "Isomerases" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
COX-2 inhibitors
Is the Subject Area "COX-2 inhibitors" applicable to this article?

Thanks for your feedback.
Enzyme assays
Is the Subject Area "Enzyme assays" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.