A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling

Christine Clark; Priit Palta; Christopher J. Joyce; Carol Scott; Elin Grundberg; Panos Deloukas; Aarno Palotie; Alison J. Coffey

doi:10.1371/journal.pone.0050233

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Open Access

Peer-reviewed

Research Article

A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip^® for Methylome Profiling

Christine Clark ,

Contributed equally to this work with: Christine Clark, Priit Palta

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Priit Palta ,

Contributed equally to this work with: Christine Clark, Priit Palta

Affiliations Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Department of Bioinformatics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
⨯
Christopher J. Joyce,

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Carol Scott,

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Elin Grundberg,

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Panos Deloukas,

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Aarno Palotie,

Affiliations Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland
⨯
Alison J. Coffey

* E-mail: ajc@sanger.ac.uk

Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯

A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip^® for Methylome Profiling

Christine Clark,
Priit Palta,
Christopher J. Joyce,
Carol Scott,
Elin Grundberg,
Panos Deloukas,
Aarno Palotie,
Alison J. Coffey

Published: November 29, 2012
https://doi.org/10.1371/journal.pone.0050233

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