Carbenoxolone Treatment Ameliorated Metabolic Syndrome in WNIN/Ob Obese Rats, but Induced Severe Fat Loss and Glucose Intolerance in Lean Rats

Siva Sankara Vara Prasad Sakamuri; Mahesh Sukapaka; Vijay Kumar Prathipati; Harishankar Nemani; Uday Kumar Putcha; Shailaja Pothana; Swarupa Rani Koppala; Lakshmi Raj Kumar Ponday; Vani Acharya; Giridharan Nappan Veetill; Vajreswari Ayyalasomayajula

doi:10.1371/journal.pone.0050216

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Peer-reviewed

Research Article

Carbenoxolone Treatment Ameliorated Metabolic Syndrome in WNIN/Ob Obese Rats, but Induced Severe Fat Loss and Glucose Intolerance in Lean Rats

Siva Sankara Vara Prasad Sakamuri,

Current address: Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, United States of America

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Mahesh Sukapaka,

Current address: Institute of Himalayan Bio-resource Technology, Palampur, Himachal Pradesh, India

Affiliation Department of Animal Physiology, National Centre for Laboratory Animal Sciences, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Vijay Kumar Prathipati,

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Harishankar Nemani,

Affiliation Department of Animal Physiology, National Centre for Laboratory Animal Sciences, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Uday Kumar Putcha,

Affiliation Department of Pathology, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabd, Andhra Pradesh, India
⨯
Shailaja Pothana,

Affiliation Department of Animal Physiology, National Centre for Laboratory Animal Sciences, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Swarupa Rani Koppala,

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Lakshmi Raj Kumar Ponday,

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Vani Acharya,

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Giridharan Nappan Veetill,

Affiliation Department of Animal Physiology, National Centre for Laboratory Animal Sciences, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯
Vajreswari Ayyalasomayajula

* E-mail: vaj_lipidresearch@yahoo.com

Affiliation Department of Biochemistry, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, Andhra Pradesh, India
⨯

Carbenoxolone Treatment Ameliorated Metabolic Syndrome in WNIN/Ob Obese Rats, but Induced Severe Fat Loss and Glucose Intolerance in Lean Rats

Siva Sankara Vara Prasad Sakamuri,
Mahesh Sukapaka,
Vijay Kumar Prathipati,
Harishankar Nemani,
Uday Kumar Putcha,
Shailaja Pothana,
Swarupa Rani Koppala,
Lakshmi Raj Kumar Ponday,
Vani Acharya,
Giridharan Nappan Veetill

Published: December 17, 2012
https://doi.org/10.1371/journal.pone.0050216

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