Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

Simone M. T. Camps; Bas E. Dutilh; Maiken C. Arendrup; Antonius J. M. M. Rijs; Eveline Snelders; Martijn A. Huynen; Paul E. Verweij; Willem J. G. Melchers

doi:10.1371/journal.pone.0050034

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Open Access

Peer-reviewed

Research Article

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

Simone M. T. Camps ,

Contributed equally to this work with: Simone M. T. Camps, Bas E. Dutilh

* E-mail: S.Camps@mmb.umcn.nl

Affiliations Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
⨯
Bas E. Dutilh ,

Contributed equally to this work with: Simone M. T. Camps, Bas E. Dutilh

Affiliation Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Maiken C. Arendrup,

Affiliation Unit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark
⨯
Antonius J. M. M. Rijs,

Affiliations Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
⨯
Eveline Snelders,

Affiliations Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
⨯
Martijn A. Huynen,

Affiliation Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Paul E. Verweij,

Affiliations Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
⨯
Willem J. G. Melchers

Affiliations Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
⨯

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

Simone M. T. Camps,
Bas E. Dutilh,
Maiken C. Arendrup,
Antonius J. M. M. Rijs,
Eveline Snelders,
Martijn A. Huynen,
Paul E. Verweij,
Willem J. G. Melchers

Published: November 30, 2012
https://doi.org/10.1371/journal.pone.0050034

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Azoles
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Aspergillus fumigatus
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Substitution mutation
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