Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

Bodi Zhang; Shahrzad Asadi; Zuyi Weng; Nikolaos Sismanopoulos; Theoharis C. Theoharides

doi:10.1371/journal.pone.0049767

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Peer-reviewed

Research Article

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

Bodi Zhang,

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
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Shahrzad Asadi,

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, United States of America
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Zuyi Weng,

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
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Nikolaos Sismanopoulos,

Current address: Department of Internal Medicine, St. Elizabeth's Medical Center, Boston, Massachusetts, United States of America

Affiliation Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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Theoharis C. Theoharides

* E-mail: theoharis.theoharides@tufts.edu

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, United States of America, Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America
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Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

Bodi Zhang,
Shahrzad Asadi,
Zuyi Weng,
Nikolaos Sismanopoulos,
Theoharis C. Theoharides

Published: December 17, 2012
https://doi.org/10.1371/journal.pone.0049767

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Mitochondria
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Mast cells
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Mitochondrial DNA
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