Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

• Gabriel C. Baltazar,

  Affiliation Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Sonia Guha,

  Affiliation Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Wennan Lu,

  Affiliation Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Jason Lim,

  Affiliation Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Kathleen Boesze-Battaglia,

  Affiliation Department of Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Alan M. Laties,

  Affiliation Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Puneet Tyagi,

  Affiliation Pharmaceutical Sciences and Ophthalmology, University of Colorado Denver, Aurora, Colorado, United States of America

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• Uday B. Kompella,

  Affiliation Pharmaceutical Sciences and Ophthalmology, University of Colorado Denver, Aurora, Colorado, United States of America

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• Claire H. Mitchell

  * E-mail: chm@exchange.upenn.edu

  Affiliations Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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