Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

James Mu; Sajjad A. Qureshi; Edward J. Brady; Eric S. Muise; Mari Rios Candelore; Guoqiang Jiang; Zhihua Li; Margaret S. Wu; Xiaodong Yang; Qing Dallas-Yang; Corey Miller; Yusheng Xiong; Ronald B. Langdon; Emma R. Parmee; Bei B. Zhang

doi:10.1371/journal.pone.0049572

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Open Access

Peer-reviewed

Research Article

Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

James Mu ,

* E-mail: yingjun_mu@merck.com

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Sajjad A. Qureshi,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Edward J. Brady,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Eric S. Muise,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Mari Rios Candelore,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Guoqiang Jiang,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Zhihua Li,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Margaret S. Wu,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Xiaodong Yang,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Qing Dallas-Yang,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Corey Miller,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Yusheng Xiong,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Ronald B. Langdon,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Emma R. Parmee,

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯
Bei B. Zhang

Affiliation Discovery and Preclinical Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, United States of America
⨯

Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

James Mu,
Sajjad A. Qureshi,
Edward J. Brady,
Eric S. Muise,
Mari Rios Candelore,
Guoqiang Jiang,
Zhihua Li,
Margaret S. Wu,
Xiaodong Yang,
Qing Dallas-Yang

Published: November 19, 2012
https://doi.org/10.1371/journal.pone.0049572

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