The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

Juncheng Wei; Yanzhi Yuan; Chaozhi Jin; Hui Chen; Ling Leng; Fuchu He; Jian Wang

doi:10.1371/journal.pone.0049567

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Peer-reviewed

Research Article

The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

Juncheng Wei ,

Contributed equally to this work with: Juncheng Wei, Yanzhi Yuan

Affiliations State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China, Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Yanzhi Yuan ,

Contributed equally to this work with: Juncheng Wei, Yanzhi Yuan

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Chaozhi Jin,

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Hui Chen,

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Ling Leng,

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Fuchu He ,

* E-mail: wangjian@nic.bmi.ac.cn (J. Wang); hefc@nic.bmi.ac.cn (FH)

Affiliations State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China, Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯
Jian Wang

* E-mail: wangjian@nic.bmi.ac.cn (J. Wang); hefc@nic.bmi.ac.cn (FH)

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
⨯

The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

Juncheng Wei,
Yanzhi Yuan,
Chaozhi Jin,
Hui Chen,
Ling Leng,
Fuchu He,
Jian Wang

Published: November 19, 2012
https://doi.org/10.1371/journal.pone.0049567

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