Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Federica Cossu; Mario Milani; Patrice Vachette; Francesca Malvezzi; Serena Grassi; Daniele Lecis; Domenico Delia; Carmelo Drago; Pierfausto Seneci; Martino Bolognesi; Eloise Mastrangelo

doi:10.1371/journal.pone.0049527

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Open Access

Peer-reviewed

Research Article

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Federica Cossu ,

Contributed equally to this work with: Federica Cossu, Mario Milani

Affiliation Department of Biosciences, University of Milano, Milano, Italy
⨯
Mario Milani ,

Contributed equally to this work with: Federica Cossu, Mario Milani

Affiliations Department of Biosciences, University of Milano, Milano, Italy, CNR-Istituto di Biofisica, Università degli Studi di Milano, Milano, Italy
⨯
Patrice Vachette,

Affiliation Institut de Biochimie et de Biophysique Moléculaire et Cellulaire, UMR8619 CNRS, Université Paris-Sud, IFR115, Orsay, France
⨯
Francesca Malvezzi,

Affiliation Department of Biosciences, University of Milano, Milano, Italy
⨯
Serena Grassi,

Affiliation Department of Biosciences, University of Milano, Milano, Italy
⨯
Daniele Lecis,

Affiliation Istituto Nazionale dei Tumori, Milano, Italy
⨯
Domenico Delia,

Affiliation Istituto Nazionale dei Tumori, Milano, Italy
⨯
Carmelo Drago,

Affiliation Centro Interdisciplinare Studi bio-molecolari e applicazioni Industriali (CISI), University of Milano, Milano, Italy
⨯
Pierfausto Seneci,

Affiliations Centro Interdisciplinare Studi bio-molecolari e applicazioni Industriali (CISI), University of Milano, Milano, Italy, Department of Organic and Industrial Chemistry, University of Milano, Milano, Italy
⨯
Martino Bolognesi,

Affiliations Department of Biosciences, University of Milano, Milano, Italy, CNR-Istituto di Biofisica, Università degli Studi di Milano, Milano, Italy
⨯
Eloise Mastrangelo

* E-mail: eloise.mastrangelo@unimi.it

Affiliations Department of Biosciences, University of Milano, Milano, Italy, CNR-Istituto di Biofisica, Università degli Studi di Milano, Milano, Italy
⨯

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Federica Cossu,
Mario Milani,
Patrice Vachette,
Francesca Malvezzi,
Serena Grassi,
Daniele Lecis,
Domenico Delia,
Carmelo Drago,
Pierfausto Seneci,
Martino Bolognesi

Published: November 15, 2012
https://doi.org/10.1371/journal.pone.0049527

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Crystal structure
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Apoptosis
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Dimers
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