Functionally Suppressive CD8 T Regulatory Cells Are Increased in Patients with Multiple Myeloma: A Cause for Immune Impairment

Karthick Raja Muthu Raja; Lenka Kubiczkova; Lucie Rihova; Martin Piskacek; Pavla Vsianska; Renata Hezova; Ludek Pour; Roman Hajek

doi:10.1371/journal.pone.0049446

Loading metrics

Open Access

Peer-reviewed

Research Article

Functionally Suppressive CD8 T Regulatory Cells Are Increased in Patients with Multiple Myeloma: A Cause for Immune Impairment

Karthick Raja Muthu Raja ,

* E-mail: rajakarthick594@gmail.com

Affiliations Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Lenka Kubiczkova,

Affiliation Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
⨯
Lucie Rihova,

Affiliations Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital, Brno, Czech Republic
⨯
Martin Piskacek,

Affiliation Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
⨯
Pavla Vsianska,

Affiliations Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital, Brno, Czech Republic
⨯
Renata Hezova,

Affiliation Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⨯
Ludek Pour,

Affiliation Department of Internal Medicine, Hemato-oncology, University Hospital, Brno, Czech Republic
⨯
Roman Hajek

Affiliations Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital, Brno, Czech Republic, Department of Internal Medicine, Hemato-oncology, University Hospital, Brno, Czech Republic
⨯

Functionally Suppressive CD8 T Regulatory Cells Are Increased in Patients with Multiple Myeloma: A Cause for Immune Impairment

Karthick Raja Muthu Raja,
Lenka Kubiczkova,
Lucie Rihova,
Martin Piskacek,
Pavla Vsianska,
Renata Hezova,
Ludek Pour,
Roman Hajek

Published: November 13, 2012
https://doi.org/10.1371/journal.pone.0049446

Reader Comments (1)

Post a new comment on this article

0 Responses

14 Nov 2012
16:19 GMT
Most Recent

Frequency and absolute number of peripheral blood CD8 T regulatory cells, CD8 T cells and total lymphocytes from multiple myeloma patients and healthy donors Posted by rajakarthick on 14 Nov 2012 at 16:19 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Multiple myeloma
Is the Subject Area "Multiple myeloma" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
T helper cells
Is the Subject Area "T helper cells" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Forkhead box
Is the Subject Area "Forkhead box" applicable to this article?

Thanks for your feedback.
Reverse transcriptase-polymerase chain reaction
Is the Subject Area "Reverse transcriptase-polymerase chain reaction" applicable to this article?

Thanks for your feedback.