Diabetes-Induced Hepatic Pathogenic Damage, Inflammation, Oxidative Stress, and Insulin Resistance Was Exacerbated in Zinc Deficient Mouse Model

Chi Zhang; Xuemian Lu; Yi Tan; Bing Li; Xiao Miao; Litai Jin; Xue Shi; Xiang Zhang; Lining Miao; Xiaokun Li; Lu Cai

doi:10.1371/journal.pone.0049257

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Peer-reviewed

Research Article

Diabetes-Induced Hepatic Pathogenic Damage, Inflammation, Oxidative Stress, and Insulin Resistance Was Exacerbated in Zinc Deficient Mouse Model

Chi Zhang,

Affiliations Ruian Center of the Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of the Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China, The Chinese-American Research Institute for Diabetic Complications, The Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China, Kosair Children Hospital Research Institute, at the Department of Pediatrics of University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Xuemian Lu,

Affiliation Ruian Center of the Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of the Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China
⨯
Yi Tan,

Affiliations The Chinese-American Research Institute for Diabetic Complications, The Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China, Kosair Children Hospital Research Institute, at the Department of Pediatrics of University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Bing Li,

Affiliations Kosair Children Hospital Research Institute, at the Department of Pediatrics of University of Louisville School of Medicine, Louisville, Kentucky, United States of America, The Second Hospital of Jilin University, Changchun, People's Republic of China
⨯
Xiao Miao,

Affiliations Kosair Children Hospital Research Institute, at the Department of Pediatrics of University of Louisville School of Medicine, Louisville, Kentucky, United States of America, The Second Hospital of Jilin University, Changchun, People's Republic of China
⨯
Litai Jin,

Affiliation The Chinese-American Research Institute for Diabetic Complications, The Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China
⨯
Xue Shi,

Affiliation Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America
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Xiang Zhang,

Affiliation Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America
⨯
Lining Miao,

Affiliation The Second Hospital of Jilin University, Changchun, People's Republic of China
⨯
Xiaokun Li ,

* E-mail: xiaokunli@163.net (XKL); l0cai001@louisville.edu (LC)

Affiliation The Chinese-American Research Institute for Diabetic Complications, The Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China
⨯
Lu Cai

* E-mail: xiaokunli@163.net (XKL); l0cai001@louisville.edu (LC)

Affiliations Ruian Center of the Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of the Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China, The Chinese-American Research Institute for Diabetic Complications, The Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China, Kosair Children Hospital Research Institute, at the Department of Pediatrics of University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Departments of Pharmacology and Toxicology, and Radiation Oncology, the University of Louisville, Louisville, Kentucky, United States of America
⨯

Diabetes-Induced Hepatic Pathogenic Damage, Inflammation, Oxidative Stress, and Insulin Resistance Was Exacerbated in Zinc Deficient Mouse Model

Chi Zhang,
Xuemian Lu,
Yi Tan,
Bing Li,
Xiao Miao,
Litai Jin,
Xue Shi,
Xiang Zhang,
Lining Miao,
Xiaokun Li

Published: December 12, 2012
https://doi.org/10.1371/journal.pone.0049257

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