The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

Open Access

Peer-reviewed

Research Article

The PDZ Protein GIPC Regulates Trafficking of the LPA₁ Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

Tal Varsano,

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Vanessa Taupin,

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Lixia Guo,

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
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Oscar Y. Baterina Jr,

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Marilyn G. Farquhar

* E-mail: mfarquhar@ucsd.edu

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯

Endosomes
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Small interfering RNA
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Transfection
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Cell membranes
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ERK signaling cascade
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Cell proliferation
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Glutathione chromatography
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Vesicles
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