GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

Edwin T. Parlevliet; Yanan Wang; Janine J. Geerling; Janny P. Schröder-Van der Elst; Kristen Picha; Karyn O'Neil; Vedrana Stojanovic-Susulic; Tatiana Ort; Louis M. Havekes; Johannes A. Romijn; Hanno Pijl; Patrick C. N. Rensen

doi:10.1371/journal.pone.0049152

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Peer-reviewed

Research Article

GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

Edwin T. Parlevliet ,

Contributed equally to this work with: Edwin T. Parlevliet, Yanan Wang

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Yanan Wang ,

Contributed equally to this work with: Edwin T. Parlevliet, Yanan Wang

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Janine J. Geerling,

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Janny P. Schröder-Van der Elst,

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Kristen Picha,

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America
⨯
Karyn O'Neil,

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America
⨯
Vedrana Stojanovic-Susulic,

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America
⨯
Tatiana Ort,

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America
⨯
Louis M. Havekes,

Affiliations Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Gaubius Laboratory, Netherlands Organization for Applied Scientific Research-Metabolic Health Research, Leiden, The Netherlands
⨯
Johannes A. Romijn,

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Hanno Pijl,

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Patrick C. N. Rensen

* E-mail: P.C.N.Rensen@lumc.nl

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯

GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

Edwin T. Parlevliet,
Yanan Wang,
Janine J. Geerling,
Janny P. Schröder-Van der Elst,
Kristen Picha,
Karyn O'Neil,
Vedrana Stojanovic-Susulic,
Tatiana Ort,
Louis M. Havekes,
Johannes A. Romijn

Published: November 2, 2012
https://doi.org/10.1371/journal.pone.0049152

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