Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

Diana Seidel; Dana Krinke; Heinz-Georg Jahnke; Anika Hirche; Daniel Kloß; Till G. A. Mack; Frank Striggow; Andrea Robitzki

doi:10.1371/journal.pone.0049150

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Open Access

Peer-reviewed

Research Article

Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

Diana Seidel ,

Contributed equally to this work with: Diana Seidel, Dana Krinke

Affiliation Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Leipzig, Germany
⨯
Dana Krinke ,

Contributed equally to this work with: Diana Seidel, Dana Krinke

Affiliation Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Leipzig, Germany
⨯
Heinz-Georg Jahnke,

Affiliation Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Leipzig, Germany
⨯
Anika Hirche,

Affiliation Translational Centre for Regenerative Medicine, University of Leipzig, Leipzig, Germany
⨯
Daniel Kloß,

Affiliation Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Leipzig, Germany
⨯
Till G. A. Mack,

Affiliations KeyNeurotek Pharmaceuticals AG, Zenit Technologiepark, Magdeburg, Germany, Department of Neurodegeneration and Intervention Strategies, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
⨯
Frank Striggow,

Affiliations KeyNeurotek Pharmaceuticals AG, Zenit Technologiepark, Magdeburg, Germany, Department of Neurodegeneration and Intervention Strategies, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
⨯
Andrea Robitzki

* E-mail: andrea.robitzki@bbz.uni-leipzig.de

Affiliation Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Leipzig, Germany
⨯

Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

Diana Seidel,
Dana Krinke,
Heinz-Georg Jahnke,
Anika Hirche,
Daniel Kloß,
Till G. A. Mack,
Frank Striggow,
Andrea Robitzki

Published: November 7, 2012
https://doi.org/10.1371/journal.pone.0049150

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