Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose

Zhaoyun Zhang; Zhihong Yang; Bo Zhu; Ji Hu; Chong Wee Liew; Yingyi Zhang; Jane A. Leopold; Diane E. Handy; Joseph Loscalzo; Robert C. Stanton

doi:10.1371/journal.pone.0049128

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Peer-reviewed

Research Article

Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose

Zhaoyun Zhang ,

Contributed equally to this work with: Zhaoyun Zhang, Zhihong Yang

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai, China
⨯
Zhihong Yang ,

Contributed equally to this work with: Zhaoyun Zhang, Zhihong Yang

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Bo Zhu,

Affiliation Division of Endocrinology and Metabolism, Nanfang Hospital, Guangzhou, China
⨯
Ji Hu,

Affiliation Division of Endocrinology and Metabolism, 2nd Affiliated Hospital of Soochow University, Suzhou, China
⨯
Chong Wee Liew,

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yingyi Zhang,

Affiliation Brigham Woman's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jane A. Leopold,

Affiliation Brigham Woman's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Diane E. Handy,

Affiliation Brigham Woman's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joseph Loscalzo,

Affiliation Brigham Woman's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Robert C. Stanton

* E-mail: robert.stanton@joslin.harvard.edu

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose

Zhaoyun Zhang,
Zhihong Yang,
Bo Zhu,
Ji Hu,
Chong Wee Liew,
Yingyi Zhang,
Jane A. Leopold,
Diane E. Handy,
Joseph Loscalzo,
Robert C. Stanton

Published: November 19, 2012
https://doi.org/10.1371/journal.pone.0049128

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