ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Open Access

Peer-reviewed

Research Article

Helena C. Christianson,

Affiliation Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden
⨯
Toin H. van Kuppevelt,

Affiliation Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Mattias Belting

* E-mail: Mattias.Belting@med.lu.se

Affiliations Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden, Skåne University Hospital and Oncology Clinic, Lund, Sweden
⨯

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Cancer treatment
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MAPK signaling cascades
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Heparin
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Hypoxia
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