Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrPSc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Sarah Vascellari; Christina D. Orrù; Andrew G. Hughson; Declan King; Rona Barron; Jason M. Wilham; Gerald S. Baron; Brent Race; Alessandra Pani; Byron Caughey

doi:10.1371/journal.pone.0048969

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Peer-reviewed

Research Article

Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP^Sc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Sarah Vascellari,

Affiliations Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy
⨯
Christina D. Orrù,

Affiliations Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy
⨯
Andrew G. Hughson,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Declan King,

Affiliation Division of Neurobiology, The Roslin Institute and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom
⨯
Rona Barron,

Affiliation Division of Neurobiology, The Roslin Institute and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom
⨯
Jason M. Wilham,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Gerald S. Baron,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Brent Race,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Alessandra Pani,

Affiliation Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy
⨯
Byron Caughey

* E-mail: bcaughey@nih.gov

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯

Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP^Sc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Sarah Vascellari,
Christina D. Orrù,
Andrew G. Hughson,
Declan King,
Rona Barron,
Jason M. Wilham,
Gerald S. Baron,
Brent Race,
Alessandra Pani,
Byron Caughey

Published: November 5, 2012
https://doi.org/10.1371/journal.pone.0048969

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Scrapie
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Animal prion diseases
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Mouse models
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Blood plasma
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Genetically modified animals
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Amyloid proteins
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Immunoprecipitation
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