Otx2 Is Involved in the Regional Specification of the Developing Retinal Pigment Epithelium by Preventing the Expression of Sox2 and Fgf8, Factors That Induce Neural Retina Differentiation

Daisuke Nishihara; Ichiro Yajima; Hiromasa Tabata; Masato Nakai; Nagaharu Tsukiji; Tatsuya Katahira; Kazuhisa Takeda; Shigeki Shibahara; Harukazu Nakamura; Hiroaki Yamamoto

doi:10.1371/journal.pone.0048879

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Peer-reviewed

Research Article

Otx2 Is Involved in the Regional Specification of the Developing Retinal Pigment Epithelium by Preventing the Expression of Sox2 and Fgf8, Factors That Induce Neural Retina Differentiation

Daisuke Nishihara,

Affiliations Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan, Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan
⨯
Ichiro Yajima,

Affiliation Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan
⨯
Hiromasa Tabata,

Affiliation Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan
⨯
Masato Nakai,

Affiliation Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan
⨯
Nagaharu Tsukiji,

Affiliation Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Tatsuya Katahira,

Affiliation Laboratory of Developmental Neurobiology, Graduate School of Brain Science, Doshisha University, Kyotanabe, Kyoto, Japan
⨯
Kazuhisa Takeda,

Affiliation Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
⨯
Shigeki Shibahara,

Affiliation Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
⨯
Harukazu Nakamura,

Affiliations Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan, Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
⨯
Hiroaki Yamamoto

* E-mail: h_yamamoto@nagahama-i-bio.ac.jp

Affiliation Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan
⨯

Otx2 Is Involved in the Regional Specification of the Developing Retinal Pigment Epithelium by Preventing the Expression of Sox2 and Fgf8, Factors That Induce Neural Retina Differentiation

Daisuke Nishihara,
Ichiro Yajima,
Hiromasa Tabata,
Masato Nakai,
Nagaharu Tsukiji,
Tatsuya Katahira,
Kazuhisa Takeda,
Shigeki Shibahara,
Harukazu Nakamura,
Hiroaki Yamamoto

Published: November 8, 2012
https://doi.org/10.1371/journal.pone.0048879

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