In a Model of Batten Disease, Palmitoyl Protein Thioesterase-1 Deficiency Is Associated with Brown Adipose Tissue and Thermoregulation Abnormalities

Alfia Khaibullina; Nicholas Kenyon; Virginia Guptill; Martha M. Quezado; Li Wang; Deloris Koziol; Robert Wesley; Pablo R. Moya; Zhongjian Zhang; Arjun Saha; Anil B. Mukherjee; Zenaide M.N. Quezado

doi:10.1371/journal.pone.0048733

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Open Access

Peer-reviewed

Research Article

In a Model of Batten Disease, Palmitoyl Protein Thioesterase-1 Deficiency Is Associated with Brown Adipose Tissue and Thermoregulation Abnormalities

Alfia Khaibullina,

Affiliation The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington District of Colmbia, United States of America
⨯
Nicholas Kenyon,

Affiliation The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington District of Colmbia, United States of America
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Virginia Guptill,

Affiliation Department of Perioperative Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Martha M. Quezado,

Affiliation Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Li Wang,

Affiliation The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington District of Colmbia, United States of America
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Deloris Koziol,

Affiliation Biostatistics and Clinical Epidemiology Service, Office of the Director, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
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Robert Wesley,

Affiliation Biostatistics and Clinical Epidemiology Service, Office of the Director, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
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Pablo R. Moya,

Affiliation Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
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Zhongjian Zhang,

Affiliation Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Arjun Saha,

Affiliation Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Anil B. Mukherjee,

Affiliation Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Zenaide M.N. Quezado

* E-mail: zquezado@cnmc.org

Affiliations The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington District of Colmbia, United States of America, Department of Perioperative Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

In a Model of Batten Disease, Palmitoyl Protein Thioesterase-1 Deficiency Is Associated with Brown Adipose Tissue and Thermoregulation Abnormalities

Alfia Khaibullina,
Nicholas Kenyon,
Virginia Guptill,
Martha M. Quezado,
Li Wang,
Deloris Koziol,
Robert Wesley,
Pablo R. Moya,
Zhongjian Zhang,
Arjun Saha

Published: November 6, 2012
https://doi.org/10.1371/journal.pone.0048733

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