The β1-Subunit of Nav1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

Aurélie Mercier; Romain Clément; Thomas Harnois; Nicolas Bourmeyster; Jean-François Faivre; Ian Findlay; Mohamed Chahine; Patrick Bois; Aurélien Chatelier

doi:10.1371/journal.pone.0048690

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Peer-reviewed

Research Article

The β₁-Subunit of Na_v1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

Aurélie Mercier,

Affiliation Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France
⨯
Romain Clément,

Affiliation Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France
⨯
Thomas Harnois,

Affiliations Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France, CHU de Poitiers, Poitiers, France
⨯
Nicolas Bourmeyster,

Affiliations Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France, CHU de Poitiers, Poitiers, France
⨯
Jean-François Faivre,

Affiliation Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France
⨯
Ian Findlay,

Affiliations Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France, Laboratoire de Physiologie des Cellules Cardiaques et Vasculaires, Institut de Physiologie et Biologie Cellulaires, FRE 3511 CNRS, Université François-Rabelais, Faculté des Sciences, Tours, France
⨯
Mohamed Chahine,

Affiliation Institut universitaire en santé mentale de Québec, Université Laval, Québec, Québec, Canada
⨯
Patrick Bois ,

Contributed equally to this work with: Patrick Bois, Aurélien Chatelier

Affiliation Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France
⨯
Aurélien Chatelier

Contributed equally to this work with: Patrick Bois, Aurélien Chatelier

* E-mail: aurelien.chatelier@univ-poitiers.fr

Affiliation Institut de Physiologie et Biologie Cellulaires, FRE 3511, CNRS/Université de Poitiers, Pôle Biologie Santé, Poitiers, France
⨯

The β₁-Subunit of Na_v1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

Aurélie Mercier,
Romain Clément,
Thomas Harnois,
Nicolas Bourmeyster,
Jean-François Faivre,
Ian Findlay,
Mohamed Chahine,
Patrick Bois,
Aurélien Chatelier

Published: November 1, 2012
https://doi.org/10.1371/journal.pone.0048690

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