Inhibition of Both Protease and Helicase Activities of Hepatitis C Virus NS3 by an Ethyl Acetate Extract of Marine Sponge Amphimedon sp

• Yuusuke Fujimoto,

  Affiliation Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

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• Kazi Abdus Salam ,

  Contributed equally to this work with: Kazi Abdus Salam, Atsushi Furuta

  Affiliation Radioisotope Center, The University of Tokyo, Tokyo, Japan

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• Atsushi Furuta ,

  Contributed equally to this work with: Kazi Abdus Salam, Atsushi Furuta

  Affiliations Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

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• Yasuyoshi Matsuda,

  Affiliations Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

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• Osamu Fujita,

  Affiliations Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

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• Hidenori Tani,

  Affiliation Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan

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• Masanori Ikeda,

  Affiliation Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

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• Nobuyuki Kato,

  Affiliation Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

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• Naoya Sakamoto,

  Affiliation Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

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• Shinya Maekawa,

  Affiliation First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

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• Nobuyuki Enomoto,

  Affiliation First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

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• Nicole J. de Voogd,

  Affiliation Netherlands Centre for Biodiversity Naturalis, Leiden, The Netherlands

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• Masamichi Nakakoshi,

  Affiliation Institute of Medical Chemistry, Hoshi University, Tokyo, Japan

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• Masayoshi Tsubuki,

  Affiliation Institute of Medical Chemistry, Hoshi University, Tokyo, Japan

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• Yuji Sekiguchi,

  Affiliation Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan

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• Satoshi Tsuneda,

  Affiliation Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

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• Nobuyoshi Akimitsu,

  Affiliation Radioisotope Center, The University of Tokyo, Tokyo, Japan

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• Naohiro Noda,

  Affiliations Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

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• Atsuya Yamashita ,

  * E-mail: atsuyay@yamanashi.ac.jp (AY); jtanaka@sci.u-ryukyu.ac.jp (JT); kmoriishi@yamanashi.ac.jp (KM)

  Affiliation Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

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• Junichi Tanaka ,

  * E-mail: atsuyay@yamanashi.ac.jp (AY); jtanaka@sci.u-ryukyu.ac.jp (JT); kmoriishi@yamanashi.ac.jp (KM)

  Affiliation Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Okinawa, Japan

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•  [ ... ],
• Kohji Moriishi

  * E-mail: atsuyay@yamanashi.ac.jp (AY); jtanaka@sci.u-ryukyu.ac.jp (JT); kmoriishi@yamanashi.ac.jp (KM)

  Affiliation Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

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