Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism

António Rego; Margarida Costa; Susana Rodrigues Chaves; Nabil Matmati; Helena Pereira; Maria João Sousa; Pedro Moradas-Ferreira; Yusuf A. Hannun; Vítor Costa; Manuela Côrte-Real

doi:10.1371/journal.pone.0048571

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Peer-reviewed

Research Article

Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism

António Rego,

Affiliations Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
⨯
Margarida Costa,

Affiliations Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Biologia Molecular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
⨯
Susana Rodrigues Chaves,

Affiliation Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
⨯
Nabil Matmati,

Affiliation Stony Brook Cancer Center, Stony Brook University, Health Science Center, Stony Brook, New York, United States of America
⨯
Helena Pereira,

Affiliation Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
⨯
Maria João Sousa,

Affiliation Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
⨯
Pedro Moradas-Ferreira,

Affiliations Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Biologia Molecular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
⨯
Yusuf A. Hannun,

Affiliation Stony Brook Cancer Center, Stony Brook University, Health Science Center, Stony Brook, New York, United States of America
⨯
Vítor Costa ,

* E-mail: vcosta@ibmc.up.pt (VC); mcortereal@bio.uminho.pt (MCR)

Affiliations Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Biologia Molecular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
⨯
Manuela Côrte-Real

* E-mail: vcosta@ibmc.up.pt (VC); mcortereal@bio.uminho.pt (MCR)

Affiliation Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
⨯

Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism

António Rego,
Margarida Costa,
Susana Rodrigues Chaves,
Nabil Matmati,
Helena Pereira,
Maria João Sousa,
Pedro Moradas-Ferreira,
Yusuf A. Hannun,
Vítor Costa,
Manuela Côrte-Real

Published: November 30, 2012
https://doi.org/10.1371/journal.pone.0048571

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Acetic acid
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Saccharomyces cerevisiae
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