Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Naoyuki Sato; Masayasu Okochi; Mitsuru Shinohara; Gopal Thinakaran; Shuko Takeda; Akio Fukumori; Motoko Shinohara-Noma; Mari Mori-Ueda; Hizuki Hamada; Masatoshi Takeda; Hiromi Rakugi; Ryuichi Morishita

doi:10.1371/journal.pone.0048551

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Open Access

Peer-reviewed

Research Article

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Naoyuki Sato ,

* E-mail: nsato@cgt.med.osaka-u.ac.jp

Affiliations Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan, Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Masayasu Okochi,

Affiliation Department of Psychiatry and Behavioral Proteomics, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Mitsuru Shinohara,

Affiliations Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan, Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Gopal Thinakaran,

Affiliation Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America
⨯
Shuko Takeda,

Affiliations Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan, Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Akio Fukumori,

Affiliation Department of Psychiatry and Behavioral Proteomics, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Motoko Shinohara-Noma,

Affiliation Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Mari Mori-Ueda,

Affiliation Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Hizuki Hamada,

Affiliation Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Masatoshi Takeda,

Affiliation Department of Psychiatry and Behavioral Proteomics, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Hiromi Rakugi,

Affiliation Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯
Ryuichi Morishita

Affiliation Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Japan
⨯

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Naoyuki Sato,
Masayasu Okochi,
Mitsuru Shinohara,
Gopal Thinakaran,
Shuko Takeda,
Akio Fukumori,
Motoko Shinohara-Noma,
Mari Mori-Ueda,
Hizuki Hamada,
Masatoshi Takeda

Published: November 12, 2012
https://doi.org/10.1371/journal.pone.0048551

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