A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice

Shi-gao Yang; Shao-wei Wang; Min Zhao; Ran Zhang; Wei-wei Zhou; Ya-nan Li; Ya-jing Su; He Zhang; Xiao-lin Yu; Rui-tian Liu

doi:10.1371/journal.pone.0048540

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Open Access

Peer-reviewed

Research Article

A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice

Shi-gao Yang ,

Contributed equally to this work with: Shi-gao Yang, Shao-wei Wang

Affiliation Tsinghua University School of Medicine, Haidian District, Beijing, China
⨯
Shao-wei Wang ,

Contributed equally to this work with: Shi-gao Yang, Shao-wei Wang

Affiliations Tsinghua University School of Medicine, Haidian District, Beijing, China, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
⨯
Min Zhao,

Affiliation Tsinghua University School of Medicine, Haidian District, Beijing, China
⨯
Ran Zhang,

Affiliation Tsinghua University School of Medicine, Haidian District, Beijing, China
⨯
Wei-wei Zhou,

Affiliation Tsinghua University School of Medicine, Haidian District, Beijing, China
⨯
Ya-nan Li,

Affiliations Tsinghua University School of Medicine, Haidian District, Beijing, China, School of Life Sciences, Ningxia University, Yinchuan, China
⨯
Ya-jing Su,

Affiliations Tsinghua University School of Medicine, Haidian District, Beijing, China, School of Life Sciences, Ningxia University, Yinchuan, China
⨯
He Zhang,

Affiliation Tsinghua University School of Medicine, Haidian District, Beijing, China
⨯
Xiao-lin Yu ,

* E-mail: rtliu@tsinghua.edu.cn (RTL); yuxiaolin@home.ipe.ac.cn (XLY)

Affiliation National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
⨯
Rui-tian Liu

* E-mail: rtliu@tsinghua.edu.cn (RTL); yuxiaolin@home.ipe.ac.cn (XLY)

Affiliations Tsinghua University School of Medicine, Haidian District, Beijing, China, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
⨯

A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice

Shi-gao Yang,
Shao-wei Wang,
Min Zhao,
Ran Zhang,
Wei-wei Zhou,
Ya-nan Li,
Ya-jing Su,
He Zhang,
Xiao-lin Yu,
Rui-tian Liu

Published: November 1, 2012
https://doi.org/10.1371/journal.pone.0048540

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