Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression

Bing Pan; Yijing Ma; Hui Ren; Yubin He; Yongyu Wang; Xiaofeng Lv; Donghui Liu; Liang Ji; Baoqi Yu; Yuhui Wang; Y. Eugene Chen; Subramaniam Pennathur; Jonathan D. Smith; George Liu; Lemin Zheng

doi:10.1371/journal.pone.0048530

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Peer-reviewed

Research Article

Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression

Bing Pan,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Institute of Systems Biomedicine, School of Basic Medical Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Yijing Ma,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Hui Ren,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Yubin He,

Affiliation The Military General Hospital of Beijing, Beijing, China
⨯
Yongyu Wang,

Affiliation Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China
⨯
Xiaofeng Lv,

Affiliation The Military General Hospital of Beijing, Beijing, China
⨯
Donghui Liu,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Liang Ji,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Baoqi Yu,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Yuhui Wang,

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Y. Eugene Chen,

Affiliation Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Subramaniam Pennathur,

Affiliation Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Jonathan D. Smith,

Affiliation Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
George Liu ,

* E-mail: zhengl@bjmu.edu.cn (LZ); georgeliu@bjmu.edu.cn (GL)

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯
Lemin Zheng

* E-mail: zhengl@bjmu.edu.cn (LZ); georgeliu@bjmu.edu.cn (GL)

Affiliations The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Institute of Systems Biomedicine, School of Basic Medical Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China
⨯

Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression

Bing Pan,
Yijing Ma,
Hui Ren,
Yubin He,
Yongyu Wang,
Xiaofeng Lv,
Donghui Liu,
Liang Ji,
Baoqi Yu,
Yuhui Wang

Published: November 2, 2012
https://doi.org/10.1371/journal.pone.0048530

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Endothelial cells
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