IP3 Receptor Type 2 Deficiency Is Associated with a Secretory Defect in the Pancreatic Acinar Cell and an Accumulation of Zymogen Granules

Abrahim I. Orabi; Yuhuan Luo; Mahwish U. Ahmad; Ahsan U. Shah; Zahir Mannan; Dong Wang; Sheharyar Sarwar; Kamaldeen A. Muili; Christine Shugrue; Thomas R. Kolodecik; Vijay P. Singh; Mark E. Lowe; Edwin Thrower; Ju Chen; Sohail Z. Husain

doi:10.1371/journal.pone.0048465

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Open Access

Peer-reviewed

Research Article

IP3 Receptor Type 2 Deficiency Is Associated with a Secretory Defect in the Pancreatic Acinar Cell and an Accumulation of Zymogen Granules

Abrahim I. Orabi,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Yuhuan Luo,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Mahwish U. Ahmad,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Ahsan U. Shah,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Zahir Mannan,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Dong Wang,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Sheharyar Sarwar,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Kamaldeen A. Muili,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Christine Shugrue,

Affiliation Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Thomas R. Kolodecik,

Affiliation Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Vijay P. Singh,

Affiliation Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Mark E. Lowe,

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Edwin Thrower,

Affiliation Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Ju Chen,

Affiliation Department of Molecular Pathology, University of California San Diego, San Diego, California, United States of America
⨯
Sohail Z. Husain

* E-mail: sohail.husain@chp.edu

Affiliation Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯

IP3 Receptor Type 2 Deficiency Is Associated with a Secretory Defect in the Pancreatic Acinar Cell and an Accumulation of Zymogen Granules

Abrahim I. Orabi,
Yuhuan Luo,
Mahwish U. Ahmad,
Ahsan U. Shah,
Zahir Mannan,
Dong Wang,
Sheharyar Sarwar,
Kamaldeen A. Muili,
Christine Shugrue,
Thomas R. Kolodecik

Published: November 21, 2012
https://doi.org/10.1371/journal.pone.0048465

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