Prime-Boost Vaccination with SA-4-1BBL Costimulatory Molecule and Survivin Eradicates Lung Carcinoma in CD8+ T and NK Cell Dependent Manner

Open Access

Peer-reviewed

Research Article

Prime-Boost Vaccination with SA-4-1BBL Costimulatory Molecule and Survivin Eradicates Lung Carcinoma in CD8⁺ T and NK Cell Dependent Manner

Abhishek K. Srivastava ,

Contributed equally to this work with: Abhishek K. Srivastava, Rajesh K. Sharma

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
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Rajesh K. Sharma ,

Contributed equally to this work with: Abhishek K. Srivastava, Rajesh K. Sharma

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
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Esma S. Yolcu,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
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Vahap Ulker,

Affiliation ApoVax Inc., Louisville, Kentucky, United States of America
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Kathryn MacLeod,

Affiliation ApoVax Inc., Louisville, Kentucky, United States of America
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Gunes Dinc,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
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Haval Shirwan

* E-mail: haval.shirwan@louisville.edu

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
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Vaccines
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T cells
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Lung and intrathoracic tumors
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Cytotoxic T cells
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Vaccination and immunization
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Cancers and neoplasms
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NK cells
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Cancer immunotherapy
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