DNA Hypomethylation Affects Cancer-Related Biological Functions and Genes Relevant in Neuroblastoma Pathogenesis

Gemma Mayol; José I. Martín-Subero; José Ríos; Ana Queiros; Marta Kulis; Mariona Suñol; Manel Esteller; Soledad Gómez; Idoia Garcia; Carmen de Torres; Eva Rodríguez; Patricia Galván; Jaume Mora; Cinzia Lavarino

doi:10.1371/journal.pone.0048401

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Open Access

Peer-reviewed

Research Article

DNA Hypomethylation Affects Cancer-Related Biological Functions and Genes Relevant in Neuroblastoma Pathogenesis

Gemma Mayol,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
José I. Martín-Subero,

Affiliation Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
⨯
José Ríos,

Affiliations Laboratory of Biostatistics and Epidemiology, Universitat Autònoma de Barcelona, Barcelona, Spain, Clinical Pharmacology Service, IDIBAPS, Hospital Clinic, Barcelona, Spain
⨯
Ana Queiros,

Affiliation Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
⨯
Marta Kulis,

Affiliation Hematopathology Unit, Hospital Clinic, Barcelona, Spain
⨯
Mariona Suñol,

Affiliation Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain
⨯
Manel Esteller,

Affiliations Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL),L'Hospitalet, Barcelona, Spain, Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
⨯
Soledad Gómez,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Idoia Garcia,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Carmen de Torres,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Eva Rodríguez,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Patricia Galván,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Jaume Mora,

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯
Cinzia Lavarino

* E-mail: clavarino@fsjd.org

Affiliation Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain
⨯

DNA Hypomethylation Affects Cancer-Related Biological Functions and Genes Relevant in Neuroblastoma Pathogenesis

Gemma Mayol,
José I. Martín-Subero,
José Ríos,
Ana Queiros,
Marta Kulis,
Mariona Suñol,
Manel Esteller,
Soledad Gómez,
Idoia Garcia,
Carmen de Torres

Published: November 7, 2012
https://doi.org/10.1371/journal.pone.0048401

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DNA methylation
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Malignant tumors
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Cancers and neoplasms
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Gene expression
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Principal component analysis
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Prostate cancer
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Epigenetics
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