An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Alexander Kirilyuk; Mika Shimoji; Jason Catania; Geetaram Sahu; Nagarajan Pattabiraman; Antonio Giordano; Christopher Albanese; Italo Mocchetti; Jeffrey A. Toretsky; Vladimir N. Uversky; Maria Laura Avantaggiati

doi:10.1371/journal.pone.0048243

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Open Access

Peer-reviewed

Research Article

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Alexander Kirilyuk,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯
Mika Shimoji,

Affiliation Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America
⨯
Jason Catania,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯
Geetaram Sahu,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯
Nagarajan Pattabiraman,

Affiliation MolBox LLC., Silver Spring, Maryland, United States of America
⨯
Antonio Giordano,

Affiliation Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Christopher Albanese,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯
Italo Mocchetti,

Affiliation Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America
⨯
Jeffrey A. Toretsky,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯
Vladimir N. Uversky ,

* E-mail: ma364@georgetown.edu (MLA); vuversky@health.usf.edu (VNU)

Affiliations Department of Molecular Medicine, University of South Florida, Tampa, Florida, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
⨯
Maria Laura Avantaggiati

* E-mail: ma364@georgetown.edu (MLA); vuversky@health.usf.edu (VNU)

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, District of Columbia, United States of America
⨯

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Alexander Kirilyuk,
Mika Shimoji,
Jason Catania,
Geetaram Sahu,
Nagarajan Pattabiraman,
Antonio Giordano,
Christopher Albanese,
Italo Mocchetti,
Jeffrey A. Toretsky,
Vladimir N. Uversky

Published: November 1, 2012
https://doi.org/10.1371/journal.pone.0048243

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Transfection
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Cytoplasmic inclusions
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Intrinsically disordered proteins
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Small interfering RNA
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Parkinson disease
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Prions
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